A study investigated the prevalence and antibiotic resistance patterns of uropathogens in patients with upper urinary tract stones and urinary tract infections (UTIs). The analysis included 1414 positive urine samples.
The most frequent pathogens identified were:
Prevalence varied by sex and age. For example, E. coli was more common in women (48.6%) than men (23.2%). E. faecalis was more frequent in younger patients.
High resistance rates were observed for levofloxacin and ciprofloxacin, while resistance to imipenem, meropenem, cefoperazone/sulbactam, piperacillin/tazobactam, and amikacin remained low. Carbapenems, cefoperazone/sulbactam, piperacillin/tazobactam, and amikacin are suggested as suitable options for severe infections.
The study also noted an increasing trend in Enterococcus faecium and decreasing trends in Staphylococcus epidermidis and Streptococcus agalactiae.
The findings highlight the importance of considering sex and age when treating UTI in patients with urinary stones. The choice of antibiotics should be guided by the observed resistance patterns.
To investigate the distribution characteristics and antibiotic resistance patterns of uropathogens in patients with upper urinary calculi and urinary tract infections, data on sex, age, positive midstream urine culture results and drug sensitivity results were collected. The statistical program SPSS 26.0 was used for statistical analysis. Among the 1414 positive urine samples, the most common pathogens were Escherichia coli (36.4%), Enterococcus faecalis (13.8%), Staphylococcus epidermidis (7.5%), Klebsiella pneumoniae (5.0%), Streptococcus agalactiae (3.4%) and Enterococcus faecium (3.3%). The incidences of E. coli (48.6%), K. pneumoniae (6.3%) and Proteus mirabilis (4.2%) were higher in female patients than in male patients (23.2%, 3.5%, 0.6%, respectively; P<0.05). E. faecalis was detected more frequently in the young group (16.0%) than in the elderly group (11.2%; P<0.01). Most of the isolates were resistant to levofloxacin and ciprofloxacin, while few were resistant to imipenem, meropenem, cefoperazone/sulbactam, piperacillin/tazobactam and amikacin. The bacterial spectra in patients with urinary stones varied by sex and age, which should be taken into consideration during treatment. The proportion of E. faecium showed an upward trend, while those of S. epidermidis and S. agalactiae demonstrated downward trends in the study period. Regardless, carbapenems, cefoperazone/sulbactam, piperacillin/tazobactam and amikacin are good choices for serious cases.
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